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US Patent 10137127 Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

Patent 10137127 was granted and assigned to Loxo Oncology on November, 2018 by the United States Patent and Trademark Office.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Mark Reynolds0

Steven A. Smith0

Date of Patent

November 27, 2018

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Patent Application Number

156225440

Date Filed

June 14, 2017

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Patent Citations Received

US Patent 11484535 Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a] pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

US Patent 10799505 Crystalline form of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate

US Patent 10813936 Crystalline form of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-YL)-pyrazolo[1,5-A]pyrimidin-3-YL)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate

US Patent 10907215 Point mutations in TRK inhibitor-resistant cancer and methods relating to the same

US Patent 10966985 Macrocyclic compounds as ROS1 kinase inhibitors

US Patent 11267818 Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds

US Patent 10588908 Methods of treating pediatric cancers

US Patent 10590139 Method of treatment using substituted imidazo[1,2b]pyridazine compounds

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Patent Primary Examiner

Leslie A. Royds Draper

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Patent abstract

A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.

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