Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yujun Zhao0
Angelo Aguilar0
Bing Zhou0
Shaomeng Wang0
Date of Patent
June 4, 2019
0Patent Application Number
155535930
Date Filed
February 26, 2016
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present disclosure provides substituted 9H-pyrimido [4,5-b] indoles and 5H-pyrido [4,3-b] indoles and related analogs represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, W, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer. The present disclosure is also directed to the use of compound of Formula I as synthetic intermediates.
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