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US Patent 10478439 Use of inhibitors of bruton's tyrosine kinase (Btk)

Patent 10478439 was granted and assigned to Pharmacyclics on November, 2019 by the United States Patent and Trademark Office.

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Patent abstract

Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

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