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US Patent 10494399 Compositions and methods for synthesizing 5′-Capped RNAS

Patent 10494399 was granted and assigned to TRILINK BIOTECHNOLOGIES, INC. on December, 2019 by the United States Patent and Trademark Office.

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Patent abstract

Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.

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