A linear locking set screw system capable of rapid linear engagement and disengagement includes a threaded outwardly expandable set screw and an expander member which are constructed and arranged to thread easily into a threaded aperture while in a first release position and can thereafter be securely locked in place and/or provide a secondary clamping force in a second engaged position. In this manner, the linear fastener system is capable of providing a precise, secure, and reproducible connection between multiple components without the need to apply rotational torque to the assembly.