Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Uwe Konietzko0
Marlen Knobloch0
Roger Nitsch0
Thomas Müggler0
Felicitas Kranz0
Jan Grimm0
Markus Rudin0
Date of Patent
September 20, 2011
Patent Application Number
12157664
Date Filed
June 11, 2008
Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided is a novel APP (amyloid precursor protein) transgenic non-human animal modeling in vivo the pathophysiological effects and effects on cognitive behavior of early intraneuronal and extracellular brain parenchymal amyloid-β (Aβ) deposition and cerebral amyloid angiopathy associated with brain microhemorrhages and reduced vasoreactivity and blood flow. Furthermore, methods of screening for therapeutic or diagnostic agents useful in the treatment or diagnosis of Alzheimer's disease, in particular for improving blood flow to the brain are provided as well as the corresponding therapeutic methods.
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