Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Sarah Mueller-Steiner0
Erik Roberson0
Lennart Mucke0
Li Gan0
Date of Patent
March 5, 2013
0Patent Application Number
128264030
Date Filed
June 29, 2010
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.