Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jennifer R. Foley0
Robert Darrin Wilson0
Date of Patent
May 7, 2013
0Patent Application Number
128119220
Date Filed
January 8, 2009
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl) transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA-damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.