HotSpot Therapeutics

HotSpot Therapeutics target regulatory mechanisms to create allosteric medicines such as small molecule molecules for treatment of autoimmune and rare diseases as well as cancer. The company’s SpotFinder technology platform is used to identify and target regulatory hotspots, a unique family of pockets situated remotely from the active site on a protein that are normally used in the body to control protein function. HotSpot’s lead compounds include allosteric inhibitors targeting PKC-theta for autoimmune diseases and S6 kinase involved in mitochondrial and metabolic function.