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Maria Stark suffered from severe problems during the conception of her child with Howard Stark. After being informed that the boy wouldn't survive birth, Howard traveled across the world desperately seeking for a way to cure his unborn child. He found himself rescuing the Rigellian Recorder 451 from the alien race known as the Greys, in exchange for means to ensure his child's survival.
451 had seen potential in the Earth, but feared that the various cosmic empires would endanger the planet before humanity could defend itself. In order to ensure humans reached their peak, 451 intended to insert someone in society to accelerate its technological growth. 451 revealed its plan to the Starks, and told them that their unborn child was the perfect candidate. After considering their options, Howard and Maria agreed to comply with 451's terms. In the course of the five-month procedure during which 451 genetically modified the baby in the womb, Howard found a hidden genetic tweak, a kill switch that would endanger the life of his son after he reached maturity. Fearing that 451 would simply better cover his tracks if confronted about it, Stark developed in secret a biococktail to neuter it, and injected it into Maria.
Some time later, baby Arno Stark was born. 451 helped deliver him, and then left the planet. The Starks were relieved with the final result, but their comfort was short-lived. Barely a few hours after Arno was born, his health quickly degenerated. When the Starks consulted with a doctor, it was determined the boy would never be able to breathe without medical assistance. Fearing the consequences if 451 ever discovered Howard's meddling, the Starks decided to keep Arno hidden in the Maria Stark Foundation Hospice and adopt a healthy son as a decoy. The adopted son became known as Tony Stark, whom the Starks tried to love like a real son.