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Stuart Little is a 1999 American live action/computer-animated comedy film loosely based on the 1945 novel of the same name by E. B. White. Directed by Rob Minkoff in his live-action debut, the screenplay was written by M. Night Shyamalan and Greg Brooker, and stars Geena Davis, Hugh Laurie, and Jonathan Lipnicki, alongside the voices of Michael J. Fox, Nathan Lane, Chazz Palminteri, Steve Zahn, Bruno Kirby, and Jennifer Tilly.
The film was released on December 17, 1999 by Columbia Pictures. The film received generally positive reviews, and was nominated for an Academy Award for Best Visual Effects, losing to The Matrix. The first film in the Stuart Little series, it was followed by a sequel Stuart Little 2 in 2002, the short-lived television series Stuart Little in 2003, and another sequel in 2005, the direct-to-video Stuart Little 3: Call of the Wild. It was Estelle Getty's final film role before her retirement in 2001 and her death in July 2008.