US Patent 10010619 Bipartite inhibitors of bacterial RNA polymerase

The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I):X-α-Y  (I)wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and α is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.