A plant cultivation system includes a first floor including a first area having an area provided with a first plant cultivation shelf, an area provided with a second plant cultivation shelf, and an area between the first plant cultivation shelf and the second plant cultivation shelf, the first floor having no air vent holes; a second floor including a second area differing from the first area, the second floor having air vent holes; and an air-conditioning unit configured to circulate air from a ceiling having air supply holes to the air vent holes in the second floor.