A computer mouse with quick-replaceable micro-switch includes a main body, a switch holder, a micro-switch and a covering panel. The main body has a lower housing, an upper housing, and an accommodation chamber formed therein. The accommodation chamber is formed with an opening on a top portion thereof. A circuit board is disposed in the main body, and has a plurality of conducting members. The switch holder is disposed in the accommodation chamber of the main body. The micro-switch is received in a receiving space of the switch holder, and has a plurality of terminals which are contacted with the conducting members. When the covering panel is removed, the micro-switch in the receiving space of the switch holder can be replaced quickly from the opening. Therefore, a user can replace the micro-switch quickly to adjust a tactile sensation when pressing the button according to personal needs.