Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jeffrey Greve0
Date of Patent
July 31, 2018
0Patent Application Number
153278130
Date Filed
August 10, 2015
0Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The invention described herein is a novel IL-2 protein with selective agonist activity for Regulatory T cells and with an additional amino acid substitution that enable chemical conjugation with Polyethyene Glycol (PEG) that increase circulating half-life compared to the IL-2 selective agonist alone. A preferred IL-2 selective agonist variant is IL2/N88R/C125S/D109C.
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