A method is provided for obtaining reference signal measurements over a structured interface to support RF optimization via machine learning. The method, performed by a network device, includes identifying a target cluster of cell towers for a radio access network (RAN); generating a model for collecting RAN measurements from mobile communication devices in the target cluster; and sending the model via a structured reference point to client applications on the mobile communication devices. The model may direct collection of and sending of the RAN measurements by the client applications. The method may further include receiving, via the structured reference point, the RAN measurements from the client applications based on the model; and aggregating the RAN measurements to represent aspects of the target cluster based on the model.