Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
August 14, 2018
Patent Application Number
14770214
Date Filed
February 26, 2014
Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided are an insulin conjugate having improved insulin receptor binding affinity and increased activity, in which a non-peptidyl polymer and an immunoglobulin Fc region are site-specifically linked to an amino acid residue of the insulin beta chain excluding the N-terminus thereof via a covalent bond, a long-acting formulation including the same, and a preparation method thereof. The insulin conjugate of the present invention is used to provide an insulin formulation which exhibits a remarkably increased in vivo activity of the peptide.
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