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US Patent 10047365 Replicative minicircle vectors with improved expression

Patent 10047365 was granted and assigned to Nature Technology Corporation on August, 2018 by the United States Patent and Trademark Office.

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Patent abstract

The present invention relates to the production and use of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly to vector modifications that improve expression of these DNA molecules.

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