Systems and methods are provided for automated segmentation of lesions within a region of interest of a patient. At least one magnetic resonance imaging (MRI) image of the region of interest is produced. At least one probability map is generated from the at least one MRI image. A given probability map represents, for each of a plurality of pixels, a likelihood that a lesion is present at the location represented by the pixel given the at least one MRI image of the region of interest. The at least one probability map is combined with a plurality of additional probability maps to provide a composite probability map. Lesions are identified from the composite probability map.