Is a
Patent attributes
Patent Applicant
Patent Jurisdiction
Patent Number
Patent Inventor Names
Wilfred Jefferies0
Reinhard Gabathuler0
Date of Patent
August 28, 2018
0Patent Application Number
153069780
Date Filed
May 1, 2015
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided are conjugates between p97 (melanotransferrin) and polynucleotides such as small interfering RNA (siRNA) molecules, and related compositions and methods of use thereof, for instance, to facilitate delivery of polynucleotides such as siRNA molecules across the blood-brain barrier (BBB) and/or improve their tissue penetration in CNS and/or peripheral tissues, and thereby treat and/or diagnose various diseases, including those having a central nervous system (CNS) component.
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