Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
September 4, 2018
Patent Application Number
15227321
Date Filed
August 3, 2016
Patent Citations Received
Patent Primary Examiner
Patent abstract
Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
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