US Patent 10082515 Peptide-lipid constructs and their use in diagnostic and therapeutic applications

Method of incorporating a water soluble construct of the structure L-S-F into the lipid bi-layer of cells by contacting a suspension of the cells with a solution of the construct at a concentration and for a time and temperature sufficient to allow the construct to insert into the lipid bi-layer. In the structure L-S-F, F is a peptide, S is a spacer containing an oligomer of ethylene glycol covalently linking F to L and the number of ethylene oxide repeats in the oligomer of ethylene glycol is 6 to 14, and L is a phosphatidylethanolamine.