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US Patent 10112983 Neuregulin variants and methods of screening and using thereof

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Patent Inventor Names

Mingdong Zhou0

Date of Patent

October 30, 2018

Patent Application Number

15097198

Date Filed

April 12, 2016

Patent Citations Received

US Patent 12076370 Compositions and methods for treating heart failure

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US Patent 10702585 Formula of neuregulin preparation

US Patent 11246909 Neuregulin based methods for treating heart failure

US Patent 11253573 Compositions and methods for treating heart failure

US Patent 11969458 Formula of neuregulin preparation

0

US Patent 10441633 Uses of neuregulin in preventing, treating or delaying ventricular arrhythmia, and composition thereof

US Patent 10561709 Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure

0

Patent Primary Examiner

Kimberly Ballard

Patent abstract

The present invention provides polypeptide variants of neuregulin-1β (NRG-1β) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4. The invention also provides methods of screening and producing polypeptide variants of NRG-1β and methods of using polypeptide variants of NRG-1β for treating diseases.

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