Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Chul-Woong Chung0
Ho Young Song0
Hyo Jung Choi0
Jeiwook Chae0
Jeong Hee Ryu0
Ji Eun Jung0
Yong Zu Kim0
Yun Hee Park0
Date of Patent
November 6, 2018
0Patent Application Number
152762310
Date Filed
September 26, 2016
0Patent Citations Received
Patent Primary Examiner
Patent abstract
In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-epidermal growth factor receptor (“EGFR”) antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the drug; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
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