The invention provides an OLED display panel and manufacturing method thereof, by disposing a red shielding color-resist block on the IGZO TFT to completely cover the active layer, able to reduce the influence of the high energy blue light incident from the top of the IGZO TFT on the active layer so as to prevent the leakage current and to ensure the TFT characteristics to maintain normal operation of the IGZO TFT. Moreover, the red shielding color-resist block covering the active layer only blocks the high-energy blue light influencing the active layer of the IGZO TFT while allows light of other bands to pass through; thus, the aperture ratio of the OLED display panel is not affected.