Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Renier J. Brentjens0
Hollie J. Jackson0
Date of Patent
November 13, 2018
0Patent Application Number
148352640
Date Filed
August 25, 2015
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to immunoresponsive cells bearing antigen receptors, which can be chimeric antigen receptors (CARS), which express introduced ligands for immunomodulatory molecules. In particular embodiments, engineered immunoresponsive cells are antigen-directed and resist immunosuppression and/or have enhances immune-activating properties.
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