Patent 10143187 was granted and assigned to Denali Therapeutics on December, 2018 by the United States Patent and Trademark Office.
In some aspects, the present invention provides chimeric transferrin receptor (TfR) polynucleotides and polypeptides. In other aspects, this invention provides chimeric TfR transgenic animal models and methods of using the animal models to identify therapeutics that can cross the blood-brain barrier.