A Base station transmits a control command for transmission of a random access preamble on a secondary cell if the base station determines radio resources of the secondary cell are required for transmission of a portion of data and that the secondary cell requires a different uplink timing from currently activated and synchronized cells of the wireless device. The base station transmits at least one control packet for comprising transport format information and resource allocation information for transmission of a plurality of packets of the data to be transmitted on the secondary cell.