Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Christopher Patrick Marshall0
Date of Patent
December 18, 2018
Patent Application Number
15424107
Date Filed
February 3, 2017
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.
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