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US Patent 10159755 RNA transcription vector and uses thereof

Patent 10159755 was granted and assigned to Vrije Universiteit Brussel on December, 2018 by the United States Patent and Trademark Office.

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Patent abstract

The present invention relates to an improved RNA transcription vector, which is very suitable for the production of mRNA for in vivo therapeutic purposes. The improvements in the vector reside in the presence of a translation enhancer (TE) and a nuclear retention element (NRS), especially when the latter is the “Expression and Nuclear Retention Element” (ENE) of Kaposi's sarcoma associated Herpes virus (KSHV).

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