A pickup cover system includes a vehicle that has a cab and a bed. A lid unit is movably coupled to the bed. A pair of lifting units is provided. Each of the lifting units is coupled between the bed and the lid unit. Moreover, each of the lifting unit selectively urges the lid unit upwardly and downwardly with respect to the bed. A wall unit is movably coupled to the lid unit. The wall unit is selectively positioned in a stored position. The wall unit is selectively positioned in a deployed position. Thus, the wall unit extends between the lid unit and the bed when the lid unit is positioned in the open position.