Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kwee Yong0
Martin Pulé0
Ben Draper0
Lydia Lee0
Date of Patent
December 25, 2018
Patent Application Number
15028064
Date Filed
October 10, 2014
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides a chimeric antigen receptor (CAR) comprising: (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular T cell signaling domain. The invention also provides the use of such a T-cell expressing such a CAR in the treatment of plasma-cell mediated diseases, such as multiple myeloma.
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