A semiconductor device includes a substrate, at least one first isolation structure, at least two second isolation structures, and a plurality of epitaxy structures. The substrate has a plurality of semiconductor fins therein. The first isolation structure is disposed between the semiconductor fins. The semiconductor fins are disposed between the second isolation structures, and the second isolation structures extend into the substrate further than the first isolation structure. The epitaxy structures are respectively disposed on the semiconductor fins. The epitaxy structures are separated from each other, and at least one of the epitaxy structures has a substantially round profile.