A method for estimating an optics point spread function (518) of a lens assembly (20) includes (i) providing a test chart (14); (ii) providing a capturing system (22); (iii) capturing a test chart image (316) of the test chart (14) with the capturing system (22) using the lens assembly (20) to focus light onto the capturing system (22); (iv) selecting an image area (490) from the test chart image (316); (v) dividing the image area (490) into a plurality of area blocks (494); and (vii) estimating an area point spread function (518) of the image area (490) using a PSF cost function that sums the fidelity terms of at least two of the area blocks (494).