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US Patent 10189797 Chemical modulators of immune checkpoints and therapeutic use

Patent 10189797 was granted and assigned to Duke University on January, 2019 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Duke University

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Current Assignee

Duke University

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Wei Chen0

Jiangbo Wang0

Robert A. Mook0

Xiu-rong Ren0

Amy Hobeika0

Herbert Kim Lyerly0

Hongtao Guo0

Date of Patent

January 29, 2019

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Patent Application Number

153954640

Date Filed

December 30, 2016

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Patent Citations Received

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US Patent 10980756 Methods of treatment

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Patent Primary Examiner

Sahar Javanmard

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Patent abstract

Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.

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