An either-handed replaceable mouse includes: a mouse body, having a first button part and a second button part, and a replaceable top cover, covering the mouse body and having a first button area and a second button area. The first button area and the second button area are correspondingly located on the first button part and the second button part respectively. During replacement of the replaceable top cover, a height from the top of the first button area on the first button part to the bottom of the mouse body is greater than or less than a height from the top of the second button area on the second button part to the bottom of the mouse body.