US Patent 10196445 Ipilimumab variant with enhanced ADCC
Patent 10196445 was granted and assigned to Bristol-Myers Squibb on February, 2019 by the United States Patent and Trademark Office.
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Patent abstract
The present invention provides anti-CTLA-4 antibodies having enhanced ADCC activity, and their use in treating cancer. In one embodiment, the anti-CTLA-4 antibody is ipilimumab, and ADCC activity is enhanced by introducing G236A, S239D, A330L and I332E mutations (“GASDALIE”) into the Fc region of the heavy chain constant domain.
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Patent Number
101964450
Date of Patent
February 5, 2019
0Patent Application Number
150714890
Date Filed
March 16, 2016
0Patent Citations Received
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Patent Jurisdiction
Patent Number
101964450
Date of Patent
February 5, 2019
0Patent Application Number
150714890
Date Filed
March 16, 2016
0Patent Citations Received
Patent Primary Examiner
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US Patent 10196445 Ipilimumab variant with enhanced ADCC
Infobox
Is a
Patent applicant
Current assignee
Patent jurisdiction
Patent number
10196445
Date of patent
February 5, 2019
Patent application number
15071489
Date Filed
March 16, 2016
Patent primary examiner
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