Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
March 19, 2019
Patent Application Number
14621337
Date Filed
February 12, 2015
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
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