Patent 10253333 was granted and assigned to Sangamo Therapeutics on April, 2019 by the United States Patent and Trademark Office.
Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.