Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Robert Yongxin Zhao0
Date of Patent
April 23, 2019
Patent Application Number
15431154
Date Filed
February 13, 2017
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
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