The present invention relates to a wire harness arrangement structure of a vehicle, comprising plural component control parts to control plural electric components for governing a drive of the vehicle, a main control part to generate a command signal for providing a command to the plural component control parts, and plural main wire harnesses to transmit the command signal. The plural electric components include at least a brake, an engine, a transmission, and a steering, and the plural main wire harnesses constitute a signal transmission loop which extends from the main control part and returns to the main control part by way of the plural component control parts.