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US Patent 10280150 Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Patent Inventor Names

Zhongguo Wang0

R. Bruce Diebold0

Susan Ashwell0

Wei Lu0

Ann-Marie Campbell0

Anna Ericsson0

David R. Lancia, Jr.0

Gary Gustafson0

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Date of Patent

May 7, 2019

Patent Application Number

15712446

Date Filed

September 22, 2017

Patent Citations

US Patent 10005734 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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Patent Citations Received

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US Patent 11498913 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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US Patent 10532047 Solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

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US Patent 10550098 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

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US Patent 10577329 Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US Patent 10807976 Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors

US Patent 10889567 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US Patent 11576906 Inhibiting mutant IDH-1

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Patent Primary Examiner

Patent abstract

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula:

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