Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
David M. Valenzuela0
Michael L. Lacroix-Fralish0
Ka-man Venus Lai0
Amanda Atanasio0
Burcin Ikiz0
Guochun Gong0
Date of Patent
May 14, 2019
Patent Application Number
15165307
Date Filed
May 26, 2016
Patent Citations Received
Patent Primary Examiner
Patent abstract
A non-human animal model for neurodegenerative and/or inflammatory diseases is provided, which non-human animal comprises a disruption in a C9ORF72 locus. In particular, non-human animals described herein comprise a deletion of an entire coding sequence of a C9ORF72 locus. Methods of identifying therapeutic candidates that may be used to prevent, delay or treat one or more neurodegenerative (e.g., amyotrophic lateral sclerosis (ALS, also referred to as Lou Gehrig's disease) and frontotemporal dementia (FTD)), autoimmune and/or inflammatory diseases (e.g., SLE, glomerulonephritis) are also provided.
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