The present invention relates in general to the field of securing structural members to masonry, and more specifically, to a drop-in anchor setting tool and method of use. The drop-in anchor setting tool includes a hands-free safety feature that allows the drop-in anchor and setting tool to remain embedded in the masonry during installation. In particular, the drop-in anchor setting tool includes a threaded portion configured to screw together the drop-in anchor and the drop-in anchor setting tool during installation. A purpose of invention is to provide a drop-in anchor setting tool and method of use that minimizes risk of injury to the operator during installation, is easy to use, and cost-effective to manufacture.