Fuel injector wear methodologies for use with internal combustion engines include a method that determines power of the engine and/or fuel flow of a fuel injector(s) associated with a cylinder the engine; obtains a duration of a fuel injection event from the injector(s) associated with the cylinder(s) of the engine; compares the power, the fuel flow, and/or the duration with a reference value; and then adjusts the fuel injection timing of the fuel injector(s), based on the comparison. Another method adjusts operation of an engine includes: comparing two (or more) engine models, wherein one model is related to a fuel injection event duration of the engine or a modeled fuel quantity being supplied to the engine and then adjusting the fuel injection timing of a fuel injector(s) of the engine, based on the comparison.