Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Robert A. Kastelein0
Edward Bowman0
Maribel Beaumont0
Marie-Ange Buyse0
Bruno Dombrecht0
Carlo Boutton0
David Vlerick0
Date of Patent
June 18, 2019
0Patent Application Number
153539190
Date Filed
November 17, 2016
0Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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