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US Patent 10330671 Modulation of synaptic maintenance

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Ben A. Barres0

Beth A. Stevens0

Date of Patent

June 25, 2019

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Patent Application Number

153498890

Date Filed

November 11, 2016

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Patent Citations Received

US Patent 11649279 Anti-complement factor C1Q antibodies and uses thereof

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US Patent 11999779 Anti-complement factor C1q Fab fragments and uses thereof

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US Patent 10927167 Anti-complement factor C1Q antibodies and uses thereof

Patent Primary Examiner

Satyanarayana R Gudibande

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Patent abstract

C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease.

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