An electrosurgical system is disclosed including an energy source and a plurality of electrodes. Each of the plurality of electrodes is coupled to the energy source and each of the plurality of electrodes is positionable for electrical contact with a target tissue. The energy source is configured to deliver, via the plurality of electrodes, a plurality of pulses of a biphasic radio frequency (RF) waveform to the target tissue. The biphasic RF waveform operates at a fundamental frequency greater than that which electrically stimulates muscular cells. The plurality of pulses induce non-thermal cell death in the target tissue without a measurable stimulation in muscular tissue exposed to the biphasic RF waveform.