A method may include accessing a terminal branch of an ophthalmic artery through a face of a subject via first device. Additionally, the method may include positioning the first device or a second device within the ophthalmic artery of the subject and treating a blockage, a stenosis, a lesion, plaque or other physiology in the ophthalmic artery or a junction between an internal carotid artery and the ophthalmic artery.