Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Piero D. Dalerba0
Jens-Peter Volkmer0
Kelly Marie McKenna0
Stephen Willingham0
Doris Po Yi Ho0
Irving L. Weissman0
Date of Patent
July 9, 2019
0Patent Application Number
153731500
Date Filed
December 8, 2016
0Patent Citations
Patent Citations Received
Patent Primary Examiner
Patent abstract
Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity; and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS or BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.
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